Skip to main content

Microsattelite Instability Reported in Sporadic Colon Tumors

1996:

H Muta et al.
Cancer 77 (2), 265-70 (15 Jan 1996)
info:pmid/8625233info:doi/10.1002/(SICI)1097-0142(19960115)77:2%3C265::AID-CNCR7%3E3.0.CO;2-L

BACKGROUND. Microsatellite instability (MI) has been reported in some sporadic colon tumors and in cases of hereditary nonpolyposis colorectal cancer (HNPCC). The criteria for HNPCC have not been fully defined, and clinical criteria are used to identify as many HNPCC patients as possible. To clarify the conformity of these criteria with the identification of eligible HNPCC cases, we analyzed MI in HNPCC patients diagnosed using clinical criteria. METHODS. Genomic DNA was extracted from surgical specimens of 56 colorectal cancers, including 36 from patients diagnosed with HNPCC using the clinical criteria. We analyzed four microsatellite loci using 32P-labeled primers. RESULTS. Among HNPCC patients diagnosed using clinical criteria, patients who were positive for MI accounted for 62% of Group A (a confirmed group) and 35% of Group B (a high risk group); only 5% of randomly selected colorectal cancer patients (Group C), were positive for MI. Furthermore, MI-positive tumors were found in patients who had a tendency for tumors to involve the right side of the colon, an association with cancers in other organs, a lower incidence of p53 protein positivity, and a higher proportion of poorly differentiated cancers. CONCLUSIONS. The presence of MI, in concert with modified clinical criteria, may identify legitimate cases of HNPCC in patients who might otherwise be excluded by the minimum criteria.
Labels:

Comments

Post a Comment

Popular posts from this blog

Cancer Survivors

Just read a story about one woman's cancer experience. I bet everyone has a story about what goes through your mind when you are told you have cancer. Her thought were about her stunned family members, one crying and the other in shock. I bet there are quite a few stories that could be qualitatively studied. Those experiences could help nurses better help patients during this time.
1 comment
Read more

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

Key Points Question    What is the frequency and spectrum of cancer susceptibility gene mutations among patients with colorectal cancer diagnosed at younger than 50 years? Findings    In this cohort study of 450 patients with early-onset colorectal cancer, 72 (16%) had a pathogenic mutation. Panel testing identified mutations in patients that may have otherwise been missed; specifically, 24 of 72 patients (33.3%) who were mutation positive did not meet testing criteria for the gene(s) in which they had a mutation. Meaning    Multigene panel testing should be considered for all patients with early-onset colorectal cancer. Read More:   Prevalence and Spectrum of Gene Mutations and Colorectal Cancer
Post a Comment
Read more

This is my one thing I can do to prevent one person from a bad outcome

My one thing is to get the message out to people who say colon cancer runs in my family....if so you need to follow through with your doctor or genetic clinic to be evaluated for hereditary colon cancer. http://www.nursingtimes.net/forums-blogs-ideas-debate/nursing-blogs/all-nurses-need-to-make-one-change-to-improve-patient-safety/5005181.article?referrer=RSS All nurses need to make one change to improve patient safety 14 August, 2009 By Suzette Woodward Suzette Woodward on how to implement just one change to aid patient safety On 3 July the health select committee published the findings of its review into patient safety over the past nine months. While this could be seen as just another report on the subject it sharply reminds us of the things we still need to do to ensure the safety of patients in the NHS. For those of us who work in this field it is an opportunity to raise the profile of patient safety and a reminder of the daunting journey we still have to make. Someone reminded m...
Post a Comment
Read more