HNPCC Info

Cancer risk is also increased in genetic forms of colon cancer. There are two known genetic forms of colon cancer: familial adeno-polyposis (FAP) and hereditary nonpolyposis colon cancer (HNPCC). Genetic inherited cancers account for 5-10% of all colon cancers (Burt, 1997). Researchers have identified single genes that lead to colon cancer susceptibility. These genes are transmitted to offspring through an autosomal dominant pattern; offspring of these carriers have a 50% chance of inheriting the gene mutation and the associated risks (Glaser, 1998).

Even though I have been diagnosed with HNPCC, I did not meet the criteria most physicians use to determine risk for HNPCC. The Amsterdam criteria is a tool used by many physicians and health care workers for determining risk for HNPCC. I would not have been high risk because I did not have a first degree relative who had colon cancer, although my twin sister had a history of polyps at 18 and 26 and I did in my 30s.