This is the group that was started on Facebook to bring awareness to HNPCC. Feel free to join this group if you are interested in raising the awareness of genetic colon cancer. We will also be investigating ways to raise funds to help those who can't afford the testing required to diagnose colon cancer.
Get the Facts: http://genefacts.org Lynch syndrome is a cancer predisposition syndrome caused by inherited mutations in genes responsible for correcting DNA replication errors. Individuals with Lynch syndrome have a greatly increased risk for colorectal, endometrial, and stomach cancers, and a moderately increased risk for other cancers. Key Points 1-3% of colon cancers attributable to Lynch syndrome Dominant inheritance with reduced penetrance (not all patients with mutations will manifest disease) Diagnosis based on clinical and family history, tumor pathology and/or genetic testing Screening and prophylactic surgeries effective in reducing some, but not all cancer risks Mutations in any of several genes can cause the syndrome
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To see whether you qualify or to make an appointment cal 918-747-5322.
If they were aware about HNPCC they would be offering it to family members who have colon cancer that runs in the family.......as another option besides age.
We need health care providers to be as aware as health care recipients.
Working on a brochure that gives more information about HNPCC, stay tuned.
Ivy
Alternative titles; symbols
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1; HNPCC1
COLON CANCER, FAMILIAL NONPOLYPOSIS, TYPE 1; FCC1
COCA1
LYNCH SYNDROME II, INCLUDED
Gene map locus 2p22-p21
TEXT
A number sign (#) is used with this entry because Lynch syndrome I, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is caused by heterozygous mutations in mismatch repair genes (MMR). HNPCC1 refers to the disorder caused by mutations in the MSH2 gene (609309).
HNPCC is a genetically heterogeneous disease. In addition to mutations in the MSH2 gene, mutations in the MLH1 (120436), PMS1 (600258), PMS2 (600259), MSH6 (600678), TFGBR2 (190182), and MLH3 (604395) genes have been identified in HNPCC. Since defects in the MSH2 gene may account for as many as 60% of HNPCC cases, and defects in the MLH1 gene may play a role in up to 30%, defects in these 2 genes likely account for the vast majority of HNPCC cases.
MD Anderson is also changing the name!
lets put the HNPCC second....Lynch Syndrome
(Hereditary Nonpolyposis Colorectal)http://www2.mdanderson.org/app/pe/index.cfm?pageName=opendoc&docid=2133
http://www.cgaicc.com/
The CGA focuses on families with rare forms of colorectal cancer, including Lynch syndrome.
National Cancer Institute (NCI)
Genetics of Colorectal Cancer
http://www.cancer.gov/cancertopics/pdq/genetics/colorectal/healthprofessional
1-800- 4-CANCER (1-800-422-6237)
Click on the link on the left hand side of the page to access more information on Lynch syndrome.
Cancer.Net