HNPCC Info

What is Lynch syndrome? Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (the endometrium). People with Lynch syndrome may occasionally have noncancerous (benign) growths (polyps) in the colon, called colon polyps. In individuals with this disorder, colon polyps occur earlier but not in greater numbers than they do in the general population. Follow this link for resources: http://ghr.nlm.nih.gov/ condition/lynch-syndrome# resources

RIP Cousin Joel Madigan Paid cash for colectomy because he had no insurance.  Survivor for 10 years, but then he couldn't afford followup care. Hard to have screening without insurance.

HNPCC Info: New Genetic Testing Guidelines For Colorectal Cancer

Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration t... Hsi-Hsien Hsu, Wei-Wen Kuo, Da-Tong Ju... World journal of gastroenterology : WJG 11/2014 20(44):16665-73. World Journal of Gastroenterology : WJG 11/2014; 20(44):16665-73. DOI: 10.3748/wjg.v20.i44.16665 Source: PubMed ABSTRACT To investigate the effects of 17β-estradiol via estrogen receptors (ER) or direct administration of ER agonists on human colorectal cancer. LoVo cells were established from the Bioresource Collection and Research Center and cultured in phenol red-free DMEM (Sigma, United States). To investigate the effects of E2 and/or ER selective agonists on cellular proliferation, LoVo colorectal cells were treated with E2 or ER-selective agonists for 24 h and 48 h and subjected to the MTT (Sigma) assay to find the concentration. And investigate the effects of E2 and/or ER selective agonists on cell used western immunoblotting to find out the diver...

Please Note:  In an effort to update this informational and personal Blog on HNPCC also known as Lynch Syndrome, many of the comments have been updated as posts. Information on Genetic Colon Cancer is changing every day and every day it affects our family in a most profound way. While the name has changed from HNPCC to a more commonly recognized Lynch Syndrome, this is just the tip of the iceberg. Our 30 year old nephew was recently diagnosed with colon cancer and new questions arose in our family.  Especially considering the fact that he is the son of my sister who's genetic testing in 2004 determined that she did not carry the gene mutation for colon cancer known to run in our family. And so, the journey continues as we continue to advocate for Colon Cancer Awareness and Lynch Syndrome and the effect that it has on the family.  More information will continue to be posted on what we are discovering and the current methodologies in screening and ...

2/25/2011   http://www.medscape.com/viewarticle/735522?src=ptalk

July 10, 2009:   Most HNPCC patients were partially adherent to intensive multi-organ screening; however, both adherent and non-adherent pts indicated their intent to initiate or resume screening. Future research will focus on assessing predictors of adherence, as well as identifying strategies to promote adherence, particularly for evidence-based tests such as colonoscopy. Their docs have to be adherent and knowledgeable too! http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=36054